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 Anaphylaxis

 Anaphylaxis FactAnaphylaxis is the term used to describe any profound rapid immune response or allergic reaction that can be fatal if left untreated. 


Anaphylaxis is an acute multi-system severe type I hypersensitivity reaction. The term comes from the Greek words ana (against) and phylaxis (protection).

Due in part to the variety of definitions, between 1% and 15% of the population of the United States can be considered "at risk" for having an anaphylactic reaction if they are exposed to one or more allergens. Of those people who actually experience anaphylaxis, up to 1% may die as a result. Anaphylaxis results in approximately 1,500 deaths per year in the U.S. In England, mortality rates for anaphylaxis have been reported as up to 0.05 per 100,000 population, or around 10-20 a year. Anaphylactic reactions requiring hospital treatment appear to be increasing, with authorities in England reporting a threefold increase between 1994 and 2004.

Based on the pathophysiology, anaphylaxis can be divided into "true anaphylaxis" and "pseudo-anaphylaxis" or "anaphylactoid reaction." The symptoms, treatment, and risk of death are the same; however, "true" anaphylaxis is caused by degranulation of mast cells or basophils mediated by immunoglobulin E (IgE), and pseudo-anaphylaxis occurs without IgE mediation.

  Related Topics

 

  Anaphylaxis Listings

The Food Allergy & Anaphylaxis Network - website full of helpful resources and links

Anaphylaxis - very straightforward and informative website

The Anaphylaxis Campaign - British website on anaphylaxis and food allergies

Anaphylaxis Canada - website devoted to information on anaphylaxis

Anaphylaxis - article provided by eMedicine

 

 

 

 

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