Antibiotic-associated diarrhea (AAD) results from an imbalance in the colonic microbiota caused by antibiotic
therapy. Microbiota alteration changes carbohydrate metabolism with decreased short-chain fatty acid absorption
and an osmotic diarrhea as a result. Another consequence of antibiotic therapy leading to diarrhea is
overgrowth of potentially pathogenic organisms such as Clostridium difficile. It is defined as frequent
loose and watery stools with no other complications.
Probiotic treatment can reduce the incidence and severity of AAD as indicated in several
meta-analyses. However, further documentation of these findings through randomized,
double blind, placebo-controlled trials are warranted.
Efficacy of probiotic AAD prevention is dependent on the probiotic strain(s) used and on the
dosage. Up to a 50% reduction of AAD occurrence has been found. No side-effects have been
reported in any of these studies. Caution should, however, be exercised when administering probiotic
supplements to immunocompromised individuals or patients who have a compromised intestinal barrier.
Clostridium difficile, also known more commonly as C-Diff, is known to account for 10 to 20 percent of
antibiotic-associated diarrhea cases. The reasoning for this, is that the antibiotics administered for
the treatment of certain diseases processes such as inflammatory colitis also inadvertently kills a
large portion of the normal flora usually present within the bowel. With this lower amount of "healthy"
bacteria present, the overgrowth of C-Diff is then responsible "for elaborating the enterotoxin."
e-malta.com is for educational purposes only; information contained within should
not be used to diagnose or treat a health problem or disease. Please consult a
licensed health care provider regarding your medical condition.
IN NO WAY SHOULD OUR WEB SITE AND ONLINE GUIDES BE CONSIDERED AS OFFERING
MEDICAL ADVICE! THE CONTENT ON THE SITE IS PRESENTED IN SUMMARY FORM, IS
GENERAL IN NATURE, AND IS PROVIDED FOR INFORMATIONAL PURPOSES ONLY. NEVER
DISREGARD MEDICAL ADVICE OR DELAY IN SEEKING IT BECAUSE OF SOMETHING YOU
HAVE READ ON THIS WEBSITE.
The materials provided at this site are for informational purposes and are not
intended for use as diagnosis or treatment of a health problem or as a
substitute for consulting a licensed medical professional. Check with a
physician if you suspect you are ill, or believe you may have one of the
problems discussed on our website, as many problems and disease states may
be serious and even life-threatening. Also note that while we frequently
update our website's content, medical information changes rapidly. Therefore,
some information may be out of date or even possibly inaccurate and erroneous.
If you find information on our site that you believe is in error, please let us
know. We make no representations or warranties with respect to any information
offered or provided on or through our website regarding treatment, action,
or application of medication. Neither e-malta.com, or any of its Members and
Affiliates will be liable for any direct, indirect, consequential, special,
exemplary, or other damages.